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Ao.Univ.-Prof. Dr. Reinhold
Wintersteiger
Building: Universitätsplatz 1, Room E03
A-8010 Graz / Austria
Tel: +43-316-380-5392 (Office)
Fax: +43-316-380-9846
e-mail:
Reinhold.Wintersteiger@uni-graz.at
Curriculum:
Mag. pharm. 1970
Dr. phil. 1973
Habilitation 1983
Ao.Univ.-Prof. 1991
Research:
- Development of sensitive and selective methods for drug determination
in biological materials
- Derivatization for electrochemical and fluorimetric detection
- Clinical pharmacy
- Environmental analysis
- Prostaglandins and phospholipids
Teaching:
- Lectures:
- PV für Dipl. und Diss.
- Privatissimum for students making their thesis or diploma
thesis
- Anl. zur Diplomarbeit aus Pharm. Chem.
- Discussion of problems within the scope of diploma thesis
- Ausgewählte Methoden der experimentellen Pharmazeutischen Chemie
- Discussion of special analytical techniques
- Einführung in die UE aus Pharmazeutischer Chemie III
(Characterization
of blood, plasma, serum, liquor and urine, enzymes and enzyme kinetics,
mechanism of inhibition, drug metabolism and analysis of metabolites,
therapeutic
drug monitoring, determination of bioavailability and bioequivalence,
determination
of different drug invasion and evasion processes, analysis of misused drugs
and dopings in biological matrix, methods of sample preparation, immunoassays,
bioassays, chromatographic and radiometric techniques, statistic parameters
in bioanalysis)
- Einf. in die Methoden der chemischen Diagnostik (Composition, functions,
physical and chemical properties of blood, methods of quantification of
endogenious compounds in blood, enzymatic and non-enzymatic determination
of substrates, determination of enzyme activity, urine analysis, possibilities
and causes of influences to bioanalysis by drugs)
- Klinische Chemie für Stud. d. Pharm. (Aspects of clinical chemistry
for students of pharmacy interested in hospital pharmacy)
- Laboratory courses:
- Anl. zur Benützung v. chem. App. u. Geräten (Detailed
practical assistence for the use of analytical instrumentation)
- Einf. in die Benützung von chemischen Apparaten und Geräten
(Practical introduction into the use of analytical instrumentation)
- UE aus Pharmazeutischer Chemie III (Determination of pK's and
isoelectric
pH's of amino acids, electrophoresis of serum proteins, determination of
thyroid hormons by enzyme immuno assay and investigation of cross reactions,
enzyme kinetics: Michaelis-Menten, Lineweaver-Burk diagram and inhibition
of enzymic reactions, determination of protein binding of drugs, quantification
of drugs by densitometry, fluorometry, HPLC, GC and other methods including
determination of recovery, accuracy and precision. Methoden der chemischen
Diagnostik Chromatographic separation and characterization of plasma amino
acids and serum lipids, non- enzymatic determination of endogenious substrates
(proteins etc.), enzymatic substrate determination (glucose, urea, uric
acid, LDL and HDL cholesterin, etc.) in serum, plasma and urine, determination
of enzyme activity (GPT, GLDH, CHE, CK, etc.) in serum and plasma,
immunological
identification of pregnancy in human urine)
Coworkers:
- Ursula Zeipper, Technician
- Karin Eggenreich, Mag. pharm., PhD student
- Mazen Hamada, Dipl. chem., PhD student
- Tanja Grobuschek, Mag. pharm., PhD student in collaboration with Prof. Juan
- Martina Butter, Mag. pharm., PhD student in collaboration with Prof. Juan
- Simone Hennerbichler, Mag. pharm., PhD student in coll. with Prof. Sedlmayr
- Dagmar Azzola, Mag. pharm., PhD student in collaboration with Prof. Sedlmayr
Subjects of Diploma thesis and PhD work:
- Determinations of cosmetric products and metabolites
- Investigations on prostaglandins, isoprostanes and phospholipids
- Development of highly sensitive methods for the determination of compounds in biological materials (phamacokinetic studies)
Pesticide analysis
- Clinical Pharmacy
Collaborations:
- Cosmital SA, Marly, Switzerland
- Centre National de la Recherche Scientific, Montpellier, France
- Institute of Biomedical Research, Prof. Juan, Univ. Graz
- Institute of Histology and Embryology, Prof. Sedlmayr, Univ. Graz
- Institute of Analytical Chemistry, Mikro- and Radiochemistry, Prof. Lankmayr,
Technical Univ. Graz
- Department of Traumatology, Dr. Schwendenwein, Univ. Vienna
- Department of Anaesthesiology, Prof Likar, LKH Klagenfurt
- Institut of Chemistry, Al-Azhar Univ., Palaestine
- Dipartimento di Scienze Farmaceutiche, Univ. Trieste, Italy
Publications:
- Determination of a hair- dye using different derivatization agents and HPLC in
combination with UV, electrochemical and fluorescence Detection Differential
phenotypic properties of human peripheral
B. Goger, R. Wintersteiger, H. Beck
Archiv der Pharmazie 11, 399-404(1999)
- Influence of isoprostanes on vasoconstrictor effects of noradrenaline and angio-
tensin II
W. Sametz, T. Grobuschek, S. Hammer-Kogler, H. Juan, R. Wintersteiger
European Journal of Pharmacology 378 47-55(1999)
- Derivatization of carboxylic-acids with fluorescent reagents
A. Knauer, R. Wintersteiger, R. Markl, W. Sametz, H. Juan
JPC-Journal of Planar Chromatography-Modern TLC 12, 211-214 (1999)
- Vascular effects of isoprostanes after endothelial damage
W. Sametz, S. Prasthofer, R. Wintersteiger, H. Juan
Prostaglandins, Leucotrienes and Essential Fatty Acids 61 (6), 369-372(1999)
- Determination of Prostaglandins by LC and Fluorescence Detection
R. Wintersteiger, A. Knauer, K. Friesenbichler, H. Juan, W. Sametz
Pharmaceutical and Pharmacological Letters 10, 1:41-44(2000)
- Influence of polyunsaturated fatty acids (PUFAs) on vasoconstrictions induced by
8-iso-PGF2a and 8-iso-PGE2
W. Sametz, M. Jeschek, H. Juan, R. Wintersteiger,
Pharmacology, 60,155-160, (2000)
- Characterisation of prostanoid receptors mediating actions of the isoprostanes,
8-iso PGE2 and 8-iso-PGE2a in some isolated smooth muscle preparations
W.Sametz, S. Hennerbichler, S. Glaser, R. Wintersteiger,
Histochem. J. 32: 71-77, (2000)
- Formation of 8-iso-PGF2a and thromboxane A2 by stimulation with several
activators of phospholipase A2 in isolated human umbilical vein.
W. Sametz, K. Humme, M. Butter, R. Wintersteiger
Br. J. Pharmacol. 131, 145-151, (2000)
- Reaction patterns of monoclonal antibodies to HLA-G in human tissues and on cell
lines: A comperative study.
A. Blaschitz, H. Hutter, V. Leitner, S. Pilz, R. Wintersteiger, G. Dohr, P. Sedlmayr
Hum. Immunol. 61, 1074-1085 (2000)
- Quantification of phenylurea pesticides by HPLC/ECD and photolysis
B. Goger, O. Kunert, Ch. Seger, R. Rinelli, R. Wintersteiger
Electronanlysis 13, No. 16,(2001) (in press)
Further information see:
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