e-mail: Gerald.Gübitz@uni-graz.at

Mag. pharm. 1966

Dr.phil. 1970

Habilitation 1980

Tit. a.o.Univ. Prof. 1991

Drug analysis:
Development of procedures for qualitative and quantitative drug analysis by instrumental techniques.

Enantiomer separation by HPLC, CE and CEC:
Synthesis of chiral selectors and chiral phases, development of new approaches for chiral separation. Application of the methods to the chiral separation of compounds of biological and pharmacological interest.

Flow-Injection, sequential-injection analysis and biosensors:
Development of chemiluminescence flow-injection and sequential-injection immunoassays and enantioselective flow-injection immunoassays, immunosensors, enzyme reactors in flow-injection systems, solid-phase chemiluminescence detection systems.

Lectures:

Einführung in die Übungen aus Pharm. Chemie II

Instrumentelle Arzneimittelanalytik

Ausgew. Kapitel der experimentellen Pharm. Chemie

Laboratory courses:

Übungen aus Pharm. Chemie II

Übungen aus Pharm. Chemie III

Instrumentelle Analysenmethoden des Arzneibuches

PV auf dem Gebiet der Arzneimittelanalytik

Exper. Met. und App. auf dem Gebiet der Arzneimittelanalytik

Anleitung zur Benützung von chem. Apparaten und Geräten

Einführung in die Benützung von chem. Apparaten und Geräten

Anleitung zur Diplomarbeit aus Pharm. Chemie

• Drug analysis
• Enantiomer separation by HPLC
• Enantiomer separation by CE
• Flow-Injection Immunoassays

• Prof. Dr. V. Schurig, University of Tübingen, Germany
• Prof. Dr. H. Y. Aboul-Enein, Bioanalytical and Drug Development Laboratory, Biological and Medical Research Department (MBC-03), King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
• Prof. Dr. G-J. Krauß, University of Halle, Germany
• Prof. Dr. F. Kilár, Medical University of Pécs, Hungary
• Doz. Dr. Th. Jira, University of Greifswald, Germany
• Prof. Dr. S. Hjerten, University of Uppsala, Sweden
• Prof. Dr. E. Golovinsky, Academy of Sciences, Sofia, Bulgaria
• Prof. Dr. D.Kaniansky, Komenius University Bratislava, Slovakia
• Participant in CEEPUS and Erasmus/Sokrates networks

• Capillary electrophoretic chiral resolution of 1,2-diols by borate-cyclodextrin complexation - comparative studies on different cyclodextrin derivatives
  M. G. Schmid, K. Wirnsberger, Th. Jira, A. Bunke and G. Gübitz Chirality 9 (1997) 153-156
• Chiral resolution of diols by capillary electrophoresis using cyclodextrin-borate complexation
  Thomas Jira, Antje Bunke, Martin G. Schmid and Gerald Gübitz J.Chromatogr. A 7661(1997) 269-275
• Precipitation Flow-Injection Immunoassay for Human IgG
  A.Hacker, G. Gübitz, J.-M. Fernandez-Romereo, M. D. Luque de Castro and M.Valcarcel Biomed. Chromatogr. II (1997) 105 -106
• Chiral separation principles in CE (Review) (Invited paper)
  G. Gübitz and M.G. Schmid J. Chromatogr., A, 792 (1997) 179 -225
• Stereoselective interaction of drug enantiomers with human serum transferrin in capillary zone electrophoresis
  M. G. Schmid, G. Gübitz and F. Kilar Electrophoresis, 19(1998) 282 - 287
• Chiral resolution of RR,SS-hydrobenzoin by liquid chromatography using borate-cyclodextrin complexation
  M.G. Schmid, K.Szabo, G. Härringer and G. Gübitz J.High Res. Chromatogr., 21(1998) 414 - 416
• Chiral separation of a-amino acids by ligand exchange capillary electrophoresis using N-(2-hydroxy-octyl)-L-4-hydroxyproline as a selector. (invited paper)
  A. Vegvari, M.G.Schmid, F. Kilar and G. Gübitz Electrophoresis, 19 (1998) 2109 -2112
• HPLC on calixarene-bonded silica gels II. Separation of regio- and stereoisomers on p-tert- butylcalix[n]arene phases
  S. Gebauer, S: Friebe, G. Gübitz and G.-J. Krauss J. Chromatogr. Sciences, 36(1998) 383 -387
• HPLC on calixarene-bonded silica gels III. Separation of cis/trans isomers of proline containing peptides
  S. Gebauer, S. Friebe, G. Scherer, G. Gübitz and G.-J. Krauss J. Chromatogr. Sciences, 36(1998) 388 -394
• Capillary electrophoretic separation of inorganic and organic arsenic compounds
  H. Greschonig, M. Schmid and G. Gübitz Fresenius J. Anal. Chem., 362 (1998) 218 - 223
• Development of solid-phase chemiluminescence immunoassays for digoxin comparing flow-injection and sequential injection techniques
  D. Dreveny, J. Michalowski, R. Seidl and G. Gübitz Analyst 123(1998) 2271 - 2276
• Enantioseparation of alpha-amino acids and dipeptides by ligand-exchange capillary electrophoresis using different L-4-hydroxyproline derivatives
  M.G. Schmid, R. Rinaldi, D. Dreveny and G. Gübitz J.Chromatogr.A 846 (1999)157 - 163
• Flow-injection- and sequential-injection immunoassay for triiodothyronine using acridinium ester chemiluminescence detection
  D. Dreveny, C. Klammer, J. Michalowsky and G. Gübitz Anal.Chim. Acta, 398(1999) 183
• Chiral separation of sympathomimetics by ligand exchange capillary electrophoresis
  M.G. Schmid, M.Laffranchini, D. Dreveny and G. Gübitz Electrophoresis, 20 (1999) 2458 -2461
• Chiral separation by capillary electrochromatography- A selective review
  M.G. Schmid and G. Gübitz Enantiomer, 5 (2000) 5-11 (invited paper)
• Application of ligand-exchange capillary electrophoresis to the chiral separation of a-hydroxy acids and ß-blockers M.G. Schmid, O. Lecnik, U.Sitte, G.Gübitz J. Chromatogr. A, 1 (2000) 307-314 (invited paper)
• Chiral separation of amino acids by ligand exchange capillary electrochromatography using continuous beds
  M. G. Schmid, N. Grobuschek, C. Tuscher, G. Gübitz, A. Vegvari, E. Machtejevas, A. Maruschka and S. Hjerten, Electrophoresis 21 (2000) 3141 ­ 3144 (invited paper)
• HPLC enantiomeric resolution of novel aromatase inhibitors on cellulose- and amylose- based chiral stationary phases under reversed phase mode
  H.Y. Aboul-Enein, I. Ali, G. Gübitz, C. Simsons, P.J. Nicholls Chirality, 12 (2000) 727 ­733
• Recent progress in chiral separation principles in capillary electrophoresis, Review
  G. Gübitz, M.G. Schmid Electrophoresis, 21 (2000) 4112 ­ 4135 (invited paper)
• Chiral separation of several thiobarbiturates on cellulose tris(methylbenzoate) phase under reversed phase mode
  H.Y. Aboul-Enein, M.G. Schmid, C. Tuscher, G. Gübitz, M. Laffranchini and J. Bojarski, J.Liq.Chromatogr. 24 (2001) 69 ­71
• Ligand-exchange capillary electrophoresis
  M.G. Schmid, N. Grobuschek, O. Lecnik, G. Gübitz J. Biochem. Biophys. Methods, 48 (2001) 143-154
• Enantioselective HPLC of therapeutically relevant amino alcohols as their fluorecent 1-naphthyl isocyanate derivatives
  T. Ullrich, G. Gübitz, G.-J-Krauß Biomed. Chromatogr., 15 (2001) 212-216
• Chiral separation of two potential aromatase inhibitors on cellulose tris(4-methylbenzoate) and cellulose tris(3,5-dimethylphenylcarbamate) phases
  H. Y. Aboul-Enein, I. Ali, M. G. Schmid, V. Jetcheva, O. Gecse, G. Gübitz, Anal. Lett., 34 (2001) 1107-1114
• Chemiluminescence Flow-Injection Immunoassays
  G. Gübitz, M.G. Schmid. H. Silvaieh , H. Aboul-Enein, Crit. Rev. Anal.Chem. 31(2001) 141-148
• Enantioseparation of hydroxy acids on easy-to-prepare continuous beds for capillary electrochromatography,
  M.G. Schmid, N. Grobuschek, O. Lecnik, G. Gübitz, A. Vegvari, S. Hjerten, Electrophoresis 22 (2001) 2616-2619
• Comparative study of the chiral resolution of beta-blockers on cellulose tris (3,5-dimethylphenylcarbamate) phases in normal and reversed phase modes,
  M. G. Schmid, O. Gecse, Z. Szabo, F. Kilar, G Gübitz, I. Ali and H. Y. Aboul-Enein, J. Liq. Chrom.&Rel. Technol., 24 (16) (2001) 2493- 2504
• Chiral separation by chromatographic and electromigration techniques. A Review,
  G. Gübitz and M.G. Schmid, Biopharmaceutics and Drug Disposition, 22 (7-8) (2001) 291-336
• Chiral separation of beta-methyl amino acids by ligand-exchange using capillary electrophoresis and HPLC,
  N. Grobuschek, M.G. Schmid, C. Tuscher, M. Ivanova, G. Gübitz, J. Pharm. Bimedical Analysis (2002) 27 599-605
• Development of enantioselective chemiluminescence flow- and sequential-injection immunoassays for alpha-amino acids,
  H. Silvaieh, M. G. Schmid, O. Hofstetter, V. Schurig, G. Gübitz, J. Biochem. Biophys. Methods, 53 (2002) 1-14
• Enantioselective sequential-injection chemiluminescence immunoassays for 3,3',5-triiodothyronine (T3) and thyroxine (T4),
  H. Silvaieh, R. Wintersteiger, M. G. Schmid, O. Hofstetter, V. Schurig, G. Gübitz, Analytica Chimica Acta (2002), 463 5-14
• Influence of structure and chirality of the selector on the chiral recognition of amino acids using ligand-exchange capillary electrophoresis,
  O. Lecnik, M.G. Schmid, A. Presser, G. Gübitz, Electrophoresis 23 (17) (2002) 3006-3012
• Chiral separation of thiazide diuretics by HPLC on Chiralcel OD-RH, Chiralcel OJ-R and Chirobiotic-T(TM) phases,
  B. Visegrady, T. Konecsni, N. Grobuschek, M. G. Schmid, F. Kilar, H. Y. Aboul-Enein, G. Gübitz, J. Biochem. Biophys. Methods 53 (2002) 15-24
• Chiral separation of bioactive cyclic Mannich ketones by HPLC and CE using cellulose derivatives and cyclodextrins as chiral selectors,
  N. Grobuschek, L. Sriphong, M. G. Schmid, T. Lorand, H. Y. Aboul-Enein, G. Gübitz, J. Biochem. Biophys. Methods 53 (2002) 25-36
• Enantioseparation of amino acids and drugs by CEC, pressure supported CEC and micro-HPLC using a teicoplanin aglycone stationary phase,
  N. Grobuschek, M. G. Schmid, J. Koidl, G. Gübitz, J. Sep. Sci 25 (15-17) (2002) 1297-1302

• Applied Bioanalytics