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Univ.-Prof. Dr. Winfried Wendelin
Building: Universitätsplatz 1, Room: 0.10
A-8010 Graz / Austria
Tel: +43-316-380-5374 (Office)
Tel: +43-316-380-5365 (Institute Secretary)
Fax: +43-316-380-9847
e-mail: Winfried.Wendelin@uni-graz.at
Technician:
Collaborator and Substitute:
Research:
Project 1:
Search for new leads: Basis Research in the
field of partly hydrogenated hetero- und carbocycles: Synthesis,
resolution, enantio- und diastereoselective syntheses, elucidation of structure
und stereochemistry by NMR, pharmacological and microbiological screening
of the prepared compounds, investigation of the
mechanism in case of highly active compounds.
Project 2:
Development of new Gyrase
inhibitors with increased antibacterial activity: Design including
molecular-modelling-studies, synthesis, elucidation of structure und stereochemistry
by NMR, molecular modelling studies with the prepared substances basing
on quantitative NOE-experiments, testing of the antibacterial activity (cooperations),
examination of the inhibition of bacterial DNA-Gyrase (cooperation).
Project 3:
Development of new inhibitors
of the ergosterol biosynthesis, type "high energy intermediate analogues":
Design including molecular-modelling-studies, synthesis, elucidation of
structure und stereochemistry by high resolution NMR, molecular modelling
studies with the prepared substances basing on quantitative NOE-experiments,
testing of the antifungal activity, examination of the inhibition of enzymes
of the ergosterol biosynthesis (FWF-project).
Project 4:
Development of new heterocyclic
anthelminthics (type fused azaheterocycles): Synthesis, elucidation of structure und stereochemistry
by NMR, testing of the anthelminthic activity (cooperation).
Project 5:
Development of new antiinflammatory drugs (type polyarylazoles and azines, and fused derivatives):
Design, synthesis, elucidation of structure and stereo-chemistry by NMR, testing of the analgesic,
antiinflammatory and spasmolytic effects (cooperations).
Collaborations:
1. Existing cooperations:
- Institut für Hygiene der Universität Graz
- Institut für
Organische Chemie und Biochemie und Institut für Pharmazie, Universität
Bonn, BRD,
- Pharmazeutisches Institut, Technische
Universität Braunschweig, BRD
- Pharmazeutisches
Institut, Universität Mainz, BRD
- Institutes of Phamaceutical
Chemistry and Organic
Technology, University of Ljubljana, Slovenija
- National Institute of Chemistry, Ljubljana, Slovenija
- Institute of Organic Chemistry, Semmelweis-Medical
University, Budapest, Hungary
- Pharmaceutical Industry
2. Wanted new cooperations:
Cooperations with laboratories of universities, research institutes
and pharmaceutical companies which are interested and potent in the screening
and testing of new compounds for all types of pharmacological, antimicrobial,
antiviral, antiparasitic, antitumor and biochemical effects and in the
cooperative development of new drugs. Cooperations with biochemical and
microbiological laboratories specialized in the testing of enzyme inhibitions
(for example with isolated enzymes of the ergosterol biosynthesis, bacterial
Gyrases, cyclooxygenases, lipoxygenases, etc.).
Note: According to preliminary tests a great number of the prepared
heterocycles exert remarkable pharmacological and biological effects (among
others hypotensive/bronchospasmolytic/antiphlogistic/diuretic/antimykotic/antiviral/antitrichomonal
and anthelminthic effects). These compounds should be submitted to further
tests and might be leads for the development of new drugs.
Publications:
- W. Wendelin, E. Gößnitzer, D. Abou El Ella, Monatsh. Chem. 131, 353 (2000).
Synthesis and Structure Elucidation of Pyrimidobenzimidazoles and Fused Derivatives II.
Dodecahydrobenzimidazo[2,1-b]quinazolines and Decahydrobenzimidazo[2,1-b]benzo[h]quinazolines
- K. Görlitzer, H. J. Baltrusch, E. Gößnitzer, W. Wendelin, Die Pharmazie 55, 35 (2000).
Eine 1-Hydroxyindol-2-carbonsäure und eine 9-Hydroxy-ß-carbolin-4-carbonsäure aus dem Nifedipinanalogen
Bis(cyanoethyl)ester
- E. Gößnitzer, W. Wendelin, Monatsh. Chem. 132, 607 (2001). Synthese und Strukturaufklärung von
Pyrimidobenzimidazolen und kondensierten Derivativen III. Decahydropyrimido[1,2-a]
benzimidazol-2-ole und Octahydropyrimido[1,2-a]benzimidazole
- E. Gößnitzer, W. Wendelin, Magn. Reson. Chem. 39, 471 (2001).
Special Reactions of a,ß-unsaturated Ketones, II. Structure and stereochemistry of
perhydro-5a,11a-epoxydibenz[b,f]oxepin-4a-ol, a bridged Diels-Alder dimer of 2-methylencyclohexanone
- E. Gößnitzer, W. Wendelin, K. Schermanz, K. Frieberger, Monatsh. Chem. 132 (2001), in press
Special Reactions of a,ß-Unsaturated Ketones, III. Formation and Structure Elucidation
of Dimers of 2-Benzylideneketones: (5E)-5-Benzylidene-9ß-phenyl-trans-4a-1,2,3,4,4a,5,6,7,8,9a-decahydroxanthen-
4aa -ol and 3ß,5ß-Bis-(4-methoxyphenyl)- 2a,4a,
6a -trimethyl-4a -propionylcyclohexanone
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